The song, about life on tour, came about when the executive producer of Honeysuckle Rose approached Nelson about writing the song. "On the Road Again" became Nelson's ninth No. 1 hit overall (sixth as a solo recording act) in November 1980, and became one of Nelson's most recognizable tunes. In addition, the song reached No. 20 on the Billboard Hot 100, becoming his biggest pop hit to that time. Nelson won Grammy Award for Best Country Song year later.